Assessment of carbamazepine acute toxicity in the cockle Cerastoderma edule through chemical, physiological and biochemical tools

Abstract The cockle Cerastoderma edule was exposed to four concentrations (5, 10, 20 and 70 μg L-1) of carbamazepine (CBZ). This anticonvulsant found alter the mussel behavior by reducing its clearance rate (CR). Analysis CBZ accumulation in tissues C. carried out using HPLC-UV after 48 or 96 hours exposure. In addition, an overproduction H2O2 bivalves detected following exposure but nitrite levels remained unchanged. Moreover, superoxide dismutase catalase activities showed a significant increase relation their contact with CBZ. activity biotransformation enzyme gluthatione-S-transferase did not change during Malondialdehyde (MDA) indicating cellular damage, increased when were l-1 for h results also indicate that acetylcholinesterase (AChE) inhibited all period. However, period, AChE only at highest concentration. Further studies are needed now more exploration toxicity since it could be bioaccumulable throughout food web may affect non-target organisms.